Abstract
Staphylococcus epidermidis is gram-positive, non motile, catalase positive, coagulase-negative and facultative anaerobe that can grow by aerobic respiration. Staphylococcus epidermidis is the dominant species that lives mostly on the skin. It colonizes predominantly the axillae, head, and nares. S. epidermidis may have a probiotic function by preventing colonization of more pathogenic bacteria such as S. aureus. Due to the secretion of biofilm it becomes virulence during device associated infections. For the antimicrobial activity of S. epidermidis 211 strains of actinobacteria were tested. Among them, 44 strains showed effective antibacterial activity against S. epidermidis including Streptomyces sp. T811, Streptomyces sp. T42, Streptomyces sp. T44, and Streptomyces sp. T812 that showed most inhibition effect. Especially two strains, T811 and T42 completely inhibited the growth of S. epidermidis after two weeks in 80% and 50% emulsion ( a cosmetic basic material). This result shows that the two strains of actinobacteria may produce antibiotics to treat skin diseases through daily makeup.
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